| 2022-05-21 19:00:37mayo 21, 2022 | C.D. Águila  | 2 - 1 |  A.D. Isidro Metapán | 19:00:377:00 pm | N/D |
| 2022-05-18 19:30:05mayo 18, 2022 | A.D. Isidro Metapán | 1 - 2 | C.D. Águila | 19:30:057:30 pm | N/D |
| 2022-05-14 19:00:52mayo 14, 2022 | A.D. Chalatenango  | 1 - 2 | A.D. Isidro Metapán | 19:00:527:00 pm | N/D |
| 2022-05-11 19:15:41mayo 11, 2022 | A.D. Isidro Metapán | 1 - 0 | A.D. Chalatenango | 19:15:417:15 pm | N/D |
| 2022-05-07 15:00:16mayo 7, 2022 | A.D. Isidro Metapán | 1 - 1 |  C.D. Atlético Marte | 15:00:163:00 pm | N/D |
| 2022-05-01 15:00:20mayo 1, 2022 | C.D. Mpal. Limeño  | 1 - 0 | A.D. Isidro Metapán | 15:00:203:00 pm | N/D |
| 2022-04-27 19:00:14abril 27, 2022 | A.D. Isidro Metapán | 0 - 0 |  Santa Tecla F.C. | 19:00:147:00 pm | N/D |
| 2022-04-23 15:15:43abril 23, 2022 | C.D. FAS  | 4 - 1 | A.D. Isidro Metapán | 15:15:433:15 pm | N/D |
| 2022-04-16 19:00:44abril 16, 2022 | A.D. Isidro Metapán | 3 - 0 |  Jocoro F.C. | 19:00:447:00 pm | N/D |
| 2022-04-13 18:00:52abril 13, 2022 | C.D. Águila | 1 - 3 | A.D. Isidro Metapán | 18:00:526:00 pm | N/D |
| 2022-04-09 19:00:28abril 9, 2022 | A.D. Isidro Metapán | 2 - 2 |  11 Deportivo FC | 19:00:287:00 pm | N/D |
| 2022-04-03 15:30:32abril 3, 2022 | C.D. Platence  | 2 - 1 | A.D. Isidro Metapán | 15:30:323:30 pm | N/D |
| 2022-03-23 19:00:17marzo 23, 2022 | A.D. Isidro Metapán | 1 - 1 |  C.D. L.A. Firpo | 19:00:177:00 pm | N/D |
| 2022-03-19 19:00:47marzo 19, 2022 | A.D. Chalatenango | 1 - 1 | A.D. Isidro Metapán | 19:00:477:00 pm | N/D |
| 2022-03-12 19:00:47marzo 12, 2022 | A.D. Isidro Metapán | 0 - 0 |  Alianza F.C. | 19:00:477:00 pm | N/D |
| 2022-03-05 15:00:31marzo 5, 2022 | C.D. Atlético Marte | 0 - 1 | A.D. Isidro Metapán | 15:00:313:00 pm | N/D |
| 2022-02-26 19:00:47febrero 26, 2022 | A.D. Isidro Metapán | 2 - 0 | C.D. Mpal. Limeño | 19:00:477:00 pm | N/D |
| 2022-02-23 19:15:02febrero 23, 2022 | Santa Tecla F.C. | 1 - 0 | A.D. Isidro Metapán | 19:15:027:15 pm | N/D |
| 2022-02-19 19:00:19febrero 19, 2022 | A.D. Isidro Metapán | 1 - 1 | C.D. FAS | 19:00:197:00 pm | N/D |
| 2022-02-12 15:00:50febrero 12, 2022 | Jocoro F.C. | 2 - 1 | A.D. Isidro Metapán | 15:00:503:00 pm | N/D |
| 2022-02-09 19:00:16febrero 9, 2022 | A.D. Isidro Metapán | 2 - 2 | C.D. Águila | 19:00:167:00 pm | N/D |
| 2022-02-06 15:00:21febrero 6, 2022 | 11 Deportivo FC | 0 - 0 | A.D. Isidro Metapán | 15:00:213:00 pm | N/D |
| 2022-01-29 19:00:18enero 29, 2022 | A.D. Isidro Metapán | 1 - 1 | C.D. Platence | 19:00:187:00 pm | N/D |
| 2022-01-26 19:00:51enero 26, 2022 | C.D. L.A. Firpo | 0 - 0 | A.D. Isidro Metapán | 19:00:517:00 pm | N/D |
| 2022-01-22 19:00:12enero 22, 2022 | A.D. Isidro Metapán | 2 - 1 | A.D. Chalatenango | 19:00:127:00 pm | N/D |
| 2022-01-16 15:00:31enero 16, 2022 | Alianza F.C. | 0 - 2 | A.D. Isidro Metapán | 15:00:313:00 pm | N/D |
| 2021-11-21 17:00:43noviembre 21, 2021 | A.D. Isidro Metapán | 1 - 2 | C.D. FAS | 17:00:435:00 pm | N/D |
| 2021-11-17 15:30:57noviembre 17, 2021 | 11 Deportivo FC | 1 - 1 | A.D. Isidro Metapán | 15:30:573:30 pm | N/D |
| 2021-11-13 19:00:29noviembre 13, 2021 | A.D. Isidro Metapán | 2 - 1 | C.D. L.A. Firpo | 19:00:297:00 pm | N/D |
| 2021-11-06 19:15:16noviembre 6, 2021 | Alianza F.C. | 1 - 0 | A.D. Isidro Metapán | 19:15:167:15 pm | N/D |
| 2021-11-02 19:00:41noviembre 2, 2021 | A.D. Isidro Metapán | 1 - 0 | C.D. Platence | 19:00:417:00 pm | N/D |
| 2021-10-30 15:00:34octubre 30, 2021 | C.D. Mpal. Limeño | 2 - 2 | A.D. Isidro Metapán | 15:00:343:00 pm | N/D |
| 2021-10-23 19:00:03octubre 23, 2021 | A.D. Isidro Metapán | 1 - 1 | Jocoro F.C. | 19:00:037:00 pm | N/D |
| 2021-10-20 19:00:38octubre 20, 2021 | C.D. Águila | 4 - 0 | A.D. Isidro Metapán | 19:00:387:00 pm | N/D |
| 2021-10-16 19:00:22octubre 16, 2021 | A.D. Isidro Metapán | 1 - 1 | Santa Tecla F.C. | 19:00:227:00 pm | N/D |
| 2021-10-02 15:15:24octubre 2, 2021 | C.D. Atlético Marte | 2 - 0 | A.D. Isidro Metapán | 15:15:243:15 pm | N/D |
| 2021-09-25 19:00:32septiembre 25, 2021 | A.D. Isidro Metapán | 1 - 4 | A.D. Chalatenango | 19:00:327:00 pm | N/D |
| 2021-09-19 15:15:41septiembre 19, 2021 | C.D. FAS | 3 - 0 | A.D. Isidro Metapán | 15:15:413:15 pm | N/D |
| 2021-09-15 19:00:34septiembre 15, 2021 | A.D. Isidro Metapán | 0 - 1 | 11 Deportivo FC | 19:00:347:00 pm | N/D |
| 2021-09-12 15:00:10septiembre 12, 2021 | C.D. L.A. Firpo | 1 - 1 | A.D. Isidro Metapán | 15:00:103:00 pm | N/D |
| 2021-08-28 19:00:32agosto 28, 2021 | A.D. Isidro Metapán | 1 - 2 | Alianza F.C. | 19:00:327:00 pm | N/D |
| 2021-08-25 15:30:35agosto 25, 2021 | C.D. Platence | 2 - 1 | A.D. Isidro Metapán | 15:30:353:30 pm | N/D |
| 2021-08-21 19:00:08agosto 21, 2021 | A.D. Isidro Metapán | 1 - 0 | C.D. Mpal. Limeño | 19:00:087:00 pm | N/D |
| 2021-08-14 15:15:04agosto 14, 2021 | Jocoro F.C. | 1 - 0 | A.D. Isidro Metapán | 15:15:043:15 pm | N/D |
| 2021-08-11 19:00:48agosto 11, 2021 | A.D. Isidro Metapán | 2 - 2 | C.D. Águila | 19:00:487:00 pm | N/D |
| 2021-08-07 19:00:37agosto 7, 2021 | Santa Tecla F.C. | 3 - 0 | A.D. Isidro Metapán | 19:00:377:00 pm | N/D |
| 2021-07-31 17:00:47julio 31, 2021 | A.D. Isidro Metapán | 0 - 0 | C.D. Atlético Marte | 17:00:475:00 pm | N/D |
